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Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects
Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects
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Date
2011
Authors
Reina, M
Ruiz-Mesia, W
Ruiz-Mesia, L
Martinez-Diaz, R
Gonzalez-Coloma, A
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Publisher
Verlag der Zeitschrift fur Naturforschung
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Abstract
Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identifi ed as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specifi c cytotoxicity against mammalian cells were also determined.
Description
This work was supported by grant CTQ2009-14629-C02-01 (Spain) and the Collaborative Research Project CSIC-CONCYTEC (Peru). W. R. M. thanks MAE-AECI (Spain) for a predoctoral fellowship. We also thank S. Carlin for language advice.
Keywords
Indole Alkaloids,
Aspidosperma rigidum,
Aspidosperma schultesii